Introduction
We have several HACCP hazard tables. Below you can see the HACCP variation table which we have composed concerning the subject ‘Mycotoxins’. Since this table is very extensive, we recommend using the download below to view the table properly.
What are Mycotoxins?
A mycotoxin (from the Gk. μύκης (mykes) “fungus”) is a poison (toxin) produced by an organism of the fungal family, such as mushrooms, filamentous fungi, and yeast. Most fungi are aerobic (they use oxygen), and are found almost everywhere in very small amounts because of their spores. Fungi can grow on crops such as grains, nuts and (legume) fruits, but can also end up in products made from them, such as bread and peanut butter.
Products are closely monitored for fungal toxins. Therefore, the risk to health is very small. The health benefits of grains, nuts and (legume) fruits far outweigh these.
Table
Mycotoxin (toxin from fungus) | Fungus | Agricultural raw materials and foodproducts | ADI of AWI (ug/kg body weight) | Effects | Legislatory regulations | Comments |
Sterigmatocystine | Aspergillus versicolor; Aspergillus ruber; Aspergillus flavus; Penicillium luteum A. nidulans, Bipolaris. | Grain, buckwheat, wheat, rice, peanut, soy, cheese, cheese crust, green coffee beans and melting cheese. | No ADI | Acute: Damage on liver, tetratogen. Chronic: mutagenic and carcinogenic. | Maximum levels according to Regulation (EC) 1881/2006 | In the Netherlands is research conducted on the presence of toxins in grain, buckwheat and soy products. Toxins are not found and therefore is control considered unnessesary. |
Patulin | Apergillus clavatus; Penicillium roqueforti; Penicillium expansum; Penicillium patulum | Apples, apple juice, beschimmelde fruits, grains, cheese and sausage | AWI: 7 (JECFA, 1989) | Acute toxic (damaging of lungs, brains, liver and kidneys); carcino- genenic effects are not found(IARC, 1985). | Maximum levels according to Regulation (EC) 1881/2006 | At fermentation of apple juice to Cider and through vitamin C takes destruction place. Dutch research didn’t found any carcinogenic effects and therefore is there no norm needed. The Patulin content can be an indication for the handling of GMP-guidelines (to establish that rotten apples are not used). |
Ergot-toxins | Claviceps purpurea; Claviceps paspali | Rye (mainly), wheat, barley, oats. | ADI: 0,001 mg/kg (Human) {2}.Medicinal: 0,125 mg/kg | Hallucinations, gangrene. Carcinogenicity is not proved yet. | Maximum levels according to Regulation (EC) 1881/2006 | Europe: last human case was in 1951. In the middle ages was it a common disease (St. Anthoniusvuur). Toxins are encapsulated by stiff purple granules. Toxin forming takes already place at agricultural level. |
Deoxynivalenol = DON (hoofdgroep: trichothecenen) | Fusarium spp. Fusarium graminearum | Wheat, barley, maize, oats, rye, rice, grain flakes and bran. | ADI Adults: 3 ADI, children: 1,5 (NRC, Canada 1985) | Acute toxic: several effects ( such as vomitting and degradating immunitiy). Possible tetragene. Carcinogenicity is not proved. | Maximum levels according to Regulation (EC) 1881/2006 | The interactions and toxicity is are relatively unknown; more research is preffered. Fusarium spp. is found on grains in temperate climates and its toxins are produced at agricultural level. |
Nivalenol =NIV (main group of trichothecenes) | Coli, Fusarium tricinctum | Wheat, barley, maize, oats, rye, rice, cereal flakes and bran. | Maximum levels according to Regulation (EC) 1881/2006 | Mostly found next to DON and toxins are produced mainly on agricultural level. | ||
Fumonisin B1, B2 and B3. | Fusarium moniliforme | Maize and maize products | Possible carcinogenic for esophagus and liver. | Maximum levels according to Regulation (EC) 1881/2006 | ||
T 2 -toxine (main group: tricho-thecenes) | Fusarium spp. | Millet, wheat, oats, barley, rye, bckwheat, peanuts, maize and sorghum. | Acute toxic: alimentary toxic aleukia (ATA) → 80% dies. Possible also mutagenic and teratogenic. | Maximum levels according to Regulation (EC) 1881/2006 | Growth of fungus is stimulated by low temperatures, especially around the freezing point. Hibernating of grains on the field is not recommended. Inactivation of toxines happens at temperatures higher than 200 °C. Inactivations of toxin at temperatures higher than 200 °C. | |
Zearalenon | Fusarium spp. among others: Fusarium graminaerum Fusarium roseum, Fusarium culmorum, Fusarium moniliforme | Maize, sorghum, wheat, barley. | Negative oestrogenic effects on fertility. Probably mutagenic, teratogenic and carcinogenic. | Maximum levels according to Regulation (EC) 1881/2006 | Forming of toxines is stimulated by temperatures for a long time around freezing point and temperature changes from low to moderate temperatures. Fungal growth happens mainly on the field but it is also possible during storage. Inactivation of the toxins happens at temperatures higher than 165 °C. | |
Rubratoxine (A and B) | Penicillium rubrum | Ground, peanuts, legumes, maize, sunflower seeds. | Acute toxic | Maximum levels according to Regulation (EC) 1881/2006 | Diseases are often found at animals who consumed contaminated animal feed. Inactivation of the toxin A happens at temperatures higher than 214 °C and toxine B at temperatures higher than 170 °C. | |
Yellow-rice-toxins (o.a. citrinine, citreo-viridine) | Penicillium spp. sometimes Aspergillus spp. Penicillium citrinum and Penicillium veridicatum. | Rice, wheat, barley and peanuts. | Citrinine: LD 50 b for rats, oral = 50 mg/kg. | Maximum levels according to Regulation (EC) 1881/2006 | Citrinine gets inactivated around Temperatures higher than 172 °C; citreoviridine at Temperatures higher than 110 °C. P.Citrinum produces exept citrinine a also a yellowish pigment that becomes fluorescent under UV-light. | |
Fycotoxins | Algea, fish products (as consequence of the food supply) especially the shellfish naturally in plants. | Toxic and or unvavorable for the bioavailability of nutrients. | Maximum levels according to Regulation (EC) 1881/2006 | Heat resistant during normal preparation treatments, occuring toxins; solanum-alkaloids in potatoes, glucosinolates in cabbage species and agaritine in mushrooms. |